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medication shown prevent migraines, but with what cost ?

Medications shown to be especially effective include the antiseizure drugs divalproex (Depakote), valproate (Depacon), and topiramate (Topamax), and the beta blockers metoprolol, propranolol, and timolol. One herbal remedy—butterbur—was also listed as an effective migraine prevention option.

Above is a paragraph written in the "Harvard health letter" all these drugs will be hard on liver brain and reniel function though there is one  "Butterbur" that has no known side effects.

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